USMLE® Step 2 CK · chapter IMM

Immunology & Allergy: USMLE® Step 2 CK topics

13 topics. Each one opens a review page with its guideline basis and key clinical sections, then links the QuestionBank questions, ChartWalk flowchart, FlashCards and ImageBank plates that share its code.

1. Anaphylaxis — clinical diagnosis without delay

   IMM-ANAPH-0122 questions · Review Book p. 490 · World Allergy Organization Anaphylaxis Guidance (2020); AAAAI/ACAAI Anaphylaxis: A 2023 Practice Parameter Update

2. Anaphylaxis — epinephrine-first treatment algorithm

   IMM-ANAPH-0249 questions · Review Book p. 492 · AAAAI/ACAAI Anaphylaxis: A 2023 Practice Parameter Update; AAAAI/ACAAI Anaphylaxis Practice Parameter (2020)

3. Angioedema — hereditary vs ACE-inhibitor vs allergic

   IMM-ANGIO-0155 questions · Review Book p. 495 · 2021 WAO/EAACI HAE International Guideline

4. Autoantibody & complement panels — interpretation

   IMM-SERO-012 questions · Review Book p. 505

5. Hypersensitivity reactions — mechanism-based recognition

   IMM-HYP-0124 questions · Review Book p. 489

6. Immunosuppressive drugs — mechanisms & toxicities

   IMM-ISUP-0114 questions · Review Book p. 508

7. Organ transplant rejection — timing & type

   IMM-TXP-0111 questions · Review Book p. 506

8. Penicillin & sulfonamide allergy — testing and cross-reactivity

   IMM-DALLERGY-0129 questions · Review Book p. 494 · 2022 AAAAI/ACAAI Drug Allergy Practice Parameters

9. Primary immunodeficiency — recognizing infection patterns

   IMM-PID-0187 questions · Review Book p. 496

10. Rheumatoid arthritis — serology, DMARD ladder & extra-articular disease

    IMM-RA-012 questions · Review Book p. 500 · 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

11. Sjögren syndrome & systemic sclerosis

    IMM-CTD-0116 questions · Review Book p. 501 · EULAR recommendations for the treatment of systemic sclerosis: 2023 update (published 2025); 2024 British Society for Rheumatology systemic sclerosis guideline

12. Systemic lupus erythematosus — diagnosis & management

    IMM-SLE-0178 questions · Review Book p. 498 · 2023 EULAR recommendations for the management of systemic lupus erythematosus; KDIGO 2024 Clinical Practice Guideline for the Management of Lupus Nephritis

13. Vasculitis — classifying by vessel size

    IMM-VASC-0178 questions · Review Book p. 503 · 2021 ACR/Vasculitis Foundation Vasculitis Guidelines

Written and clinically reviewed by TheCodexes.com (editorial policy). Guideline citations are the primary sources each topic follows.