USMLE® Step 2 CK · chapter MULTI

Multisystem & Critical Care: USMLE® Step 2 CK topics

21 topics. Each one opens a review page with its guideline basis and key clinical sections, then links the QuestionBank questions, ChartWalk flowchart, FlashCards and ImageBank plates that share its code.

1. Antibiotic stewardship — de-escalation & duration

   MULTI-ABX-0118 questions · Review Book p. 655 · CDC Core Elements of Antibiotic Stewardship

2. Bacterial meningitis — empiric therapy by age

   MULTI-MEN-0126 questions · Review Book p. 652 · 2004 IDSA Bacterial Meningitis Guidelines; 2017 IDSA Healthcare-Associated Ventriculitis/Meningitis

3. Chromosomal disorders — recognition & surveillance

   MULTI-GEN-0121 questions · Review Book p. 672 · 2022 AAP Down Syndrome Health Supervision Guideline

4. Congenital, perinatal & neonatal infections

   MULTI-CONG-0115 questions · Review Book p. 666 · AAP Red Book2024–2027; AAP congenital CMV report2026; CDC STI guidance; ACOG/SMFM RhIG2024

5. Drug-induced hyperthermia — malignant hyperthermia (MH), NMS & serotonin syndrome

   MULTI-HYPER-0112 questions · Review Book p. 680 · Current MHAUS acute-crisis + safe-anesthetic recommendations; MHAUS post-crisis dantrolene 2017.

6. Drug-resistant organisms — MRSA, VRE, HAP vs CAP

   MULTI-ABX-0214 questions · Review Book p. 657 · 2025 ATS Community-Acquired Pneumonia Guideline; 2016 IDSA/ATS HAP/VAP Guidelines

7. Fever without a source — pediatric age-based workup

   MULTI-FEVER-012 questions · Review Book p. 651 · 2021 AAP Febrile Infant Clinical Practice Guideline

8. Fluid & electrolyte repletion — IV fluids & maintenance

   MULTI-FE-017 questions · Review Book p. 677 · 2026 Surviving Sepsis Campaign; 2024 ADA/EASD Hyperglycemic Crises Consensus; 2022 Society for Endocrinology Hyponatremia Guideline; Holliday-Segar Maintenance Fluid Method

9. Fungal infections — treatment ladder by organism

   MULTI-FUNGAL-0116 questions · Review Book p. 669 · IDSA candidiasis/aspergillosis/coccidioidomycosis2016; histoplasmosis2025/Sept2026; ECMM mucormycosis2019; NIH OI guidance2026

10. Genitourinary infections — STIs, UTI & PID

    MULTI-GU-0124 questions · Review Book p. 663 · 2021 CDC STI Treatment Guidelines

11. Heat illness, hypothermia & drowning

    MULTI-ENV-0128 questions · Review Book p. 679 · 2021 ACSM Heat Illness Position Statement; 2019 WMS Accidental Hypothermia Guidelines

12. HIV/AIDS — testing, antiretroviral therapy (ART) initiation & post-exposure prophylaxis (PEP)

    MULTI-HIV-0170 questions · Review Book p. 660 · DHHS Antiretroviral Guidelines — Adults and Adolescents with HIV

13. Immunization schedules, contraindications & special hosts

    MULTI-VAX-0135 questions · Review Book p. 668 · CDC immunization guidance checked14Oct2026; July2025 schedules restored by March2026 court order (April2026 RSV amendment); vaccine-specific guidance as cited

14. Inborn errors of metabolism & inheritance patterns

    MULTI-GEN-026 questions · Review Book p. 674 · 2023 HHS Recommended Uniform Screening Panel

15. Infectious diarrhea & C. difficile management

    MULTI-GI-0111 questions · Review Book p. 665 · IDSA/SHEA CDI2017/2021; ACG CDI2021; AGA microbiota therapies2024

16. Nutritional support — enteral, parenteral & refeeding

    MULTI-NUTR-0121 questions · Review Book p. 675 · 2022 ASPEN/SCCM Critical Care Nutrition Guidelines

17. Obesity pharmacotherapy & metabolic management

    MULTI-NUTR-0214 questions · Review Book p. 676 · 2022 AGA Obesity Pharmacotherapy Guideline; 2016 AACE/ACE

18. Other & rare infectious entities

    MULTI-MISC-0141 questions · Review Book p. 670 · 2020 IDSA/AAN/ACR Lyme Disease Guidelines; 2021 AASLD Practice Guidance: Ascites, Spontaneous Bacterial Peritonitis (SBP), and Hepatorenal Syndrome

19. Sepsis & septic shock — Sepsis-3, bundle & adjuncts

    MULTI-SEP-0136 questions · Review Book p. 653 · 2026 Surviving Sepsis Campaign; Sepsis-3 (2016)

20. Skin & soft-tissue infections to necrotizing fasciitis

    MULTI-SSTI-014 questions · Review Book p. 658 · 2014 IDSA SSTI Guidelines

21. Tuberculosis — diagnosis, empiric therapy & toxicity

    MULTI-TB-0121 questions · Review Book p. 661 · 2025 ATS/CDC/ERS/IDSA Tuberculosis Treatment Guidelines

Written and clinically reviewed by TheCodexes.com (editorial policy). Guideline citations are the primary sources each topic follows.