USMLE® Step 2 CK · chapter HEME

Hematology & Oncology: USMLE® Step 2 CK topics

16 topics. Each one opens a review page with its guideline basis and key clinical sections, then links the QuestionBank questions, ChartWalk flowchart, FlashCards and ImageBank plates that share its code.

1. Anemia — classify by MCV before treating

   HEME-ANEM-0124 questions · Review Book p. 459 · AABB Red Blood Cell Transfusion Guidelines (2023)

2. Bleeding patient — interpreting PT, PTT & mixing studies

   HEME-COAG-0119 questions · Review Book p. 468

3. Blood product selection, thresholds & massive transfusion

   HEME-TRANS-028 questions · Review Book p. 476 · 2023 AABB International Guidelines for Red Blood Cell Transfusion

4. Hemolytic anemia — G6PD, spherocytosis & AIHA

   HEME-HEMOL-0116 questions · Review Book p. 463 · 2020 First International Consensus Report on AIHA; 2023 WHO G6PD Classification

5. Hemophilia A/B and von Willebrand disease

   HEME-COAG-029 questions · Review Book p. 470 · 2020 WFH Guidelines for the Management of Hemophilia, third edition; 2021 ASH/ISTH/NHF/WFH von Willebrand Disease Guidelines

6. Immune thrombocytopenia (ITP) in children and adults

   HEME-PLT-0118 questions · Review Book p. 473 · 2019 ASH ITP (pediatric/diagnostic scope); 2026 ASH Adult Initial/Second-Line Therapy; 2026 Critical-Bleeding Guideline

7. Iron deficiency vs thalassemia trait vs anemia of chronic disease

   HEME-ANEM-0234 questions · Review Book p. 461 · AGA Gastrointestinal Evaluation of Iron Deficiency Anemia (2020); British Society of Gastroenterology adult IDA guideline (2021)

8. Iron overload, porphyria & rare heme/onc entities

   HEME-MISC-0110 questions · Review Book p. 486 · 2022 EASL Hemochromatosis; 2023 AGA Acute Hepatic Porphyria; 2014 IMWG MM Criteria; 2026 ASCO MM Living Guideline

9. Leukemia — acute and chronic subtypes

   HEME-MALIG-0111 questions · Review Book p. 478 · ELN APL (2019), AML (2022), adult ALL (2024) + CML (2025)

10. Lymphoma — Hodgkin versus non-Hodgkin

    HEME-MALIG-029 questions · Review Book p. 480

11. Myeloproliferative neoplasms, polycythemia vera & MDS

    HEME-MPN-011 questions · Review Book p. 482

12. Oncologic emergencies — TLS, neutropenic fever, cord compression

    HEME-ONC-0135 questions · Review Book p. 483 · IDSA febrile neutropenia (2010) + ASCO/IDSA outpatient update (2018); BSH tumor lysis syndrome (2025) + Cairo–Bishop criteria (2004)

13. Sickle cell crises — pain, chest syndrome, priapism

    HEME-SICK-0215 questions · Review Book p. 466 · 2014 NHLBI Sickle Cell Disease Guidelines; ASH SCD pain, transfusion + cerebrovascular guidelines (2020)

14. Sickle cell disease — chronic disease-modifying therapy

    HEME-SICK-0111 questions · Review Book p. 464 · 2014 NHLBI Expert Panel Report; 2019–2021 ASH sickle cell disease Guidelines (cerebrovascular 2020, transfusion 2020, HSCT 2021)

15. Transfusion reactions — recognize and manage

    HEME-TRANS-0146 questions · Review Book p. 474

16. TTP, HUS & DIC — microangiopathic syndromes

    HEME-MAHA-0133 questions · Review Book p. 471 · ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura (2020); 2025 focused update of the 2020 ISTH guidelines for management of thrombotic thrombocytopenic purpura

Written and clinically reviewed by TheCodexes.com (editorial policy). Guideline citations are the primary sources each topic follows.